Allosteric Signaling and Mutation Analysis

Exploring and quantifying the effects of allosteric ligand binding and mutations

NEWS: Updated computations for sequence dependent model (JCP 2023) are now available! Please refer to the new tab "Sequence Dependent Model" on the top menu bar.

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Before proceeding, please take a moment to check that the input file follows the required format as described here.
Any deviation may cause the server to behave in unpredictable ways.

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Please upload the session Job-ID.zip file:


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Analyzing large proteins may take some time. Users can exit and return later to check results using the Job ID (and email, if provided) through the Restore Session function (see Tutorial Restore Session). Pages may load slowly, so thank you for your patience. For questions, contact the webmaster at dongbx [AT] bii.a-star.edu.sg, carbon copying to igornberezovsky77 [AT] gmail.com and teewv [AT] bii.a-star.edu.sg.